[ad_1] Caused by the severe acute respiratory syndrome agent coronavirus 2 (SARS-CoV-2), the 2019 coronavirus disease (COVID-19) pandemic has reached over 191 countries and infected more than 63.98 million people. Scientists around the world are racing to better understand the virus, how it is transmitted and how it affects the …
Read More »SARS-CoV-2 N439K mutation may be more infectious and resistant to antibodies than Wuhan strain
[ad_1] Researchers studied the effect of several SARS-CoV-2 mutations on its binding to the human angiotensin 2 converting enzyme using molecular dynamics simulations. They found that the N439K mutant binds more strongly than the original Wuhan strain, which could have implications for therapies such as monoclonal antibodies. The 2019 coronavirus …
Read More »COVID-19 potentially has negative impacts on male fertility
[ad_1] A review recently posted on Journal of Medical Virology discussed some of the effects infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease 2019 (COVID-19), can have on male fertility. In the paper, Cemile Seymen of the Gazi University Institute of Health Sciences, …
Read More »Natural products and herbal medicines show promise in the fight against COVID-19
[ad_1] Researchers in China and the United States have called for further research on the potential prophylactic effects of natural products and herbal medicines on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent coronavirus disease. 2019 (COVID-19). In an article recently published in the journal Frontiers in pharmacology, …
Read More »Novel mutations in SARS-CoV-2 may explain the high pathogenicity of COVID-19
[ad_1] Researchers in Korea and the United States have identified new genetic variants that demonstrate active mutational progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease 2019 (COVID-19). Two of the mutations occurred in the receptor binding domain of the viral spike protein, the …
Read More »The exploitation of proteomics could improve therapeutic approaches to COVID-19
[ad_1] A research team in India recently described how the field of proteomics could be pivotal in helping tackle the current 2019 coronavirus (COVID-19) pandemic. Since the COVID-19 outbreak was declared a pandemic by the World Health Organization (WHO) on 11 Marchth, 2020, scientists have struggled to develop therapies for …
Read More »Nafamostat mesylate initially reduces SARS-CoV-2 viral load in hamsters, according to study
[ad_1] The researchers found that nafamostat mesylate, when injected into the nasal cavity of Syrian hamsters, can reduce the initial viral load of SARS-CoV-2 in the nose. However, this effect was temporary and further tests are needed to determine clinically significant effects. The hunt group results are available on the …
Read More »Identification of antibody-resistant SARS-CoV-2 spike protein mutations
[ad_1] Using a number of different monoclonal antibodies, the researchers determined several mutations in the SARS-CoV-2 spike protein that leads to resistance. Understanding these resistant mutations is important for the development of effective therapeutic strategies. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, infects host cells …
Read More »ACE2 and TMPRSS2 are not the only viral receptors mediating the entry of SARS-CoV-2
[ad_1] Most vaccine research in the current 2019 coronavirus (COVID-19) pandemic has focused on the role of the angiotensin converting enzyme 2 (ACE2) receptor in mediating viral entry into the host cell. However, a recent study published on the prepress server bioRxiv* in November 2020 discovers the major role played …
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