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Some vials from which the serum was administered did not have the same vaccine concentration as others, so some volunteers received lower doses. About 2,741 volunteers received a first dose at half the strength, while the second dose was complete.
Surprisingly, it was found that those with a lower dose were better protected by the vaccine, i.e. with an efficiency of 90% compared to an efficiency of 62% of the volunteers with high doses. This means a combined efficiency of 70% of the vaccine. 8,895 volunteers were vaccinated with serum at the established concentration.
The first results of clinical trials on volunteers in the UK and Brazil were announced on Monday, with an average vaccine estimate of 90%. The company did not mention the manufacturing errors that produced this data, although it did say that some of the volunteers received the first half of the dose.
Another factor that could have an impact on these preliminary findings is age: people in the lower dose group are volunteers up to age 55. This factor may have contributed to greater efficiency given the youth’s stronger immune response and not necessarily the size itself, writes CBC Canada.
The effectiveness of the vaccine is tested with different serum concentrations to reach the optimal doses.
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