[ad_1] Researchers in China and the United States have called for further research on the potential prophylactic effects of natural products and herbal medicines on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent coronavirus disease. 2019 (COVID-19). In an article recently published in the journal Frontiers in pharmacology, …
Read More »The first Phase 3 advanced anal cancer study opens for patient enrollment
[ad_1] Reviewed by Emily Henderson, B.Sc.November 16, 2020 The first ever randomized Phase 3 clinical trial in patients with advanced anal canal cancer is now open and enrolling patients. Anal cancer is a rare disease. The vast majority (90%) of new cases are of the squamous cell type, associated with …
Read More »Novel mutations in SARS-CoV-2 may explain the high pathogenicity of COVID-19
[ad_1] Researchers in Korea and the United States have identified new genetic variants that demonstrate active mutational progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease 2019 (COVID-19). Two of the mutations occurred in the receptor binding domain of the viral spike protein, the …
Read More »Research shows a unique repertoire of T cell receptors in MIS-C patients
[ad_1] Children with coronavirus disease 2019 (COVID-19) sometimes develop multisystem inflammatory syndrome in children (MIS-C), which is associated with high morbidity. The underlying mechanism associated with T cells is described by the researchers in a new study published on the prepress server bioRxiv* in November 2020, in response to superantigen …
Read More »Biologists study how molecular chaperones dissolve protein aggregates linked to Parkinson’s
[ad_1] Reviewed by Emily Henderson, B.Sc.November 11, 2020 In many neurodegenerative diseases such as Parkinson’s, protein aggregates form in the brain and are assumed to contribute to neuronal cell death. Yet there is a cellular defense mechanism that counteracts these aggregates, known as amyloid fibrils, and can even dissolve the …
Read More »Researchers discover a potential genetic target for the treatment of endometriosis
[ad_1] Reviewed by Emily Henderson, B.Sc.November 11, 2020 Michigan State University researchers have identified a potential genetic target for the treatment of a particularly painful and invasive form of endometriosis. Their study published in Cell reports, a scientific journal, could lead to better treatments for women suffering from severe forms …
Read More »SARS-CoV-2 spike glycoprotein optimized for conditions found in human airways
[ad_1] Belgian and German researchers have shown how the glycoprotein peak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is fine-tuned based on human airway temperature and protease conditions, which in turn improves viral transmission and the consequent pathology. Their study is available on bioRxiv * prepress server. The rapid …
Read More »Identification of antibody-resistant SARS-CoV-2 spike protein mutations
[ad_1] Using a number of different monoclonal antibodies, the researchers determined several mutations in the SARS-CoV-2 spike protein that leads to resistance. Understanding these resistant mutations is important for the development of effective therapeutic strategies. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, infects host cells …
Read More »ACE2 and TMPRSS2 are not the only viral receptors mediating the entry of SARS-CoV-2
[ad_1] Most vaccine research in the current 2019 coronavirus (COVID-19) pandemic has focused on the role of the angiotensin converting enzyme 2 (ACE2) receptor in mediating viral entry into the host cell. However, a recent study published on the prepress server bioRxiv* in November 2020 discovers the major role played …
Read More »The study shows that oxidizing hydrogen peroxide can actually slow down cellular aging
[ad_1] Reviewed by Emily Henderson, B.Sc.November 9, 2020 At high concentrations, reactive oxygen species – known as oxidants – are harmful to the cells of all organisms and have been linked to aging. But a study from Chalmers University of Technology, Sweden, has now shown that low levels of oxidizing …
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