Insights into the search for new antibiotics – ScienceDaily

“The rapid spread of antibiotic-resistant bacteria in clinics challenges our modern medicine, and traditional approaches to antibiotic discovery fail to generate new drugs needed to treat antibiotic-resistant infections,” Zgurskaya said. “The current COVID-19 pandemic further amplifies this problem because patients in intensive care units are particularly vulnerable to such infections … (our) team is working on developing new tools to guide the discovery and optimization of new antibacterial agents.

Zgurskaya adds that the increasing frequency of antibiotic resistance has created a significant health challenge and will progressively worsen without innovative solutions.

“In particular, Gram-negative pathogens present biological and chemical challenges that hinder the discovery of new antibacterial drugs,” Zgurskaya said. “As a result of these challenges, intensive screening campaigns have yielded little success, highlighting the need for novel approaches to identify regions of the chemical space that are specifically relevant for antibacterial drug discovery.”

In the article, the research team provides an overview of emerging insights into this problem and outlines a general approach for researchers and scientists to address it.

“The overall goal is to develop robust cheminformatics tools to predict Gram-negative permeation and efflux, which can then be used to guide pharmaceutical chemistry campaigns and the design of antibacterial discovery libraries,” Zgurskaya said.

The research was supported with funding from the United States Department of Health and Human Services and the National Institutes of Health. The article, Defining a New Chemical Space for Drug Penetration in Gram Negative Bacteria, is available in the November 2020 issue of the academic journal, Chemical biology of nature.

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