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Summary
Infectious diseases can pose a devastating threat to human health around the world. As the risk increases, the world is running out of effective drugs to treat infections caused by deadly microbes. Many existing drugs have been made obsolete by the rapid emergence and spread of drug resistance. Hence, there is a desperate need for new drugs with which to treat infectious diseases. This is especially urgent for mushroom killers. There are only three main classes of antifungal drugs, and resistance is rampant, leading to the deaths of ∼1.5 million people each year (1, 2). Success in developing effective new treatments depends on creative approaches, including those that exploit chemical diversity in nature, tuned to millions of years of evolution. In this spirit, on page 974 of this issue, Zhang et al. (3) has set out on a mission to discover new antifungals produced by bacteria that inhabit marine animals.
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