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Our knees are very prone to age-related or wear-related injuries, which often leads to the need for surgery. Now, the researchers have created biological attributes that can be used for 3D printing structures to replace damaged knee cartilage. In a study validating a new concept, researchers from the Wake Forest Institute for Regenerative Medicine (WFIRM) demonstrated a new 3D printing method that creates both cartilage and supporting structures.
The team used the Integrated Tissue and Organ Printing System (ITOPS), which has been used in previous studies to print complex tissues such as bones, muscles and even ears. The researchers used several bioataments together to print the entire fibrocarded tissue layer by layer in an interlaced hatch pattern. The first composite layer consisted of gellan rubber and fibrinogen which supported the repopulation of its own cells in the body.
The second bioarm is fibroin methacrylate, which helps keep the structure strong and flexible. Under laboratory conditions, the cells were able to multiply and remain viable, and the biomechanics of the structure were preserved. Subsequent experiments involved the implantation of printed structures in mice. Observations for 10 weeks after surgery showed that the mice began regenerating their fibroartillate as expected. The research was published in a journal Chemistry of materials.
Source: newatlas.com.
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