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In a recent communication, Dr. Jean-Michel Wendling examines the impact of vitamin D deficiency on the data collected in the clinical picture of the patients included in the studies.
He wonders about the biases of studies:
“All double-blind studies could theoretically be biased if serum vitamin D factor were not taken into account to compare the molecule against the placebo groups. “
For him, this information is fundamental and if it has not been taken into account, it is equivalent to comparing a series of young patients and older patients without knowing the patient’s age:
” a randomized trial requires comparison of two identical risk groups, so lack of vitamin D dosage early on leads to the study is open to criticism. “
Dr. Wendling goes further and points it out
‘Professor Didier Raoult is undoubtedly right when he states that during an epidemic of an unknown nature with unknown confounding factors, the randomized test method is not necessarily suitable and that the latter is more relevant for diseases with which we have more perspective. “
A series of studies featured on GrassrootsHealth.net discuss the links between vitamin D deficiency and severe forms of Covid. In the study illustrated below (April 2020), it can be seen that patients with vitamin D deficiency have more ordinary to severe forms of Covid. 96% of patients with a mild form of Covid have no vitamin D deficiency (> 30 ng / ml) compared to 4 and 7% for ordinary to severe forms. The more pronounced the deficiency (<20ng / ml) the more critical the form of Covid.
Dr. Jean-Michel Wendling concludes
A second study Ye et al confirmed this same effect on a smaller sample.
Reduce the severity of death and illness with vitamin D supplementation prior to the diagnosis of COVID-19: 4.5 times greater risk of death from COVID-19 in people without vitamin D than in those who receive regular supplementation before diagnosis
With Covid-19, several risk factors such as age and a low vitamin D level partly explain the severity of the disease and its consequences / A recently published study focused on frail elderly patients hospitalized for COVID-19 to see what effect, if any, previous vitamin D supplementation in the past year and post-diagnosis supplementation had on survival and disease severity.
This study, by Annweiler et al., Included data from 77 patients, aged 78 to 100 years, consecutively admitted to a geriatric unit for COVID-19. Patients were assigned to one of three groups; Group 1 had taken bolus doses of vitamin D regularly for the past year (50,000 IU per month or 80,000 or 100,000 IU every 2-3 months) and subsequently received no additional vitamin D. diagnosed with COVID-19, group 2 received 80,000 IU of vitamin D within hours of COVID-19 diagnosis, and group 3 received no vitamin D supplementation before or after the diagnosis. There was no significant difference between the groups at baseline except for gender, and all patients received similar standard treatments for COVID-19. The survival rate after 14 days was measured, as well as the severity of the disease symptoms in the worst phase,
Those who took vitamin D regularly prior to diagnosis had the best results. In total, by day 14, 17 patients had experienced severe COVID-19 and 15 patients died.
Do children’s vitamin D levels affect their chances of contracting COVID-19 and its severity?
Although children do not tend to be severely affected by the SARS-CoV-2 virus and the subsequent effects of COVID-19, they are certainly not immune and there are concerns that children with the virus but asymptomatic contribute to its spread.
Children are also not “ immune ” to vitamin D deficiency – in fact, a previous article shared data from the U.S. NHANES dataset showing that vitamin D levels decline with age, with a 4-fold increase in the proportion of children under 20 ng / ml (50 nmol / L) from 0 to 4 years to 13-17 years.
How do children’s vitamin D levels affect their COVID-19 status?
To answer this question, Kamil Yilmaz and Velat Sen conducted a study in which they recruited 85 children aged 1 month to 18 years, 40 of whom were diagnosed with COVID-19 and were hospitalized, and 45 who were witnesses. to greet. Children with chronic diseases and other comorbidities were excluded from the study.
Children diagnosed with COVID-19 were divided into two groups for analysis: Group 1 included children who had vitamin D levels below 20 ng / mL, and group 2 included those whose levels were equal to or greater of 20 ng / ml.
What did the study find?
The study found a significant difference in vitamin D levels between children with COVID-19, who had a median level of 13 ng / ml (32 nmol / L), and the control group, with a median level of 35 ng. / ml (87 nmol / L).
When disease severity in children diagnosed with COVID-19 was analyzed by vitamin D level, a trend was found showing greater disease severity for those with vitamin D levels. Indeed, among those with Vitamin D levels below 20 ng / mL (50 nmol / L), 31% of children had moderate to severe symptoms of COVID-19, compared with only 18% with moderate symptoms (none had classified as severe) for children with vitamin D levels of 20 ng / ml or more. Additionally, 46% of children with higher vitamin D levels were asymptomatic, compared with 10% of those with lower vitamin D levels.
The study also found a significant negative correlation between vitamin D level and the risk of having a fever (defined as a temperature above 100.4 F or 38 C, p = 0.023), meaning that when vitamin D increased, the risk of fever decreased. Overall, none of the children with a vitamin D level of at least 20 ng / mL had a fever, while 34.5% of those with a level of less than 20 ng / mL had it.
It is therefore important to ensure vitamin D levels of 40 to 60 ng / ml (100 to 150 nmol / L) for you, your children and your loved ones.
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