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Researchers from the Liverpool School of Tropical Medicine conducted a study showing that a new disinfectant called Virusend TX-10 is highly effective in inactivating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for it. current coronavirus disease 2019 (covid19.
The study showed that Virusend TX-10 reduced SARS-CoV-2 titers on surfaces and in solution below the detection limit within just one minute of contact.
Edward Patterson and colleagues say ensuring that disinfectants such as Virusend TX-10 are effective in inactivating SARS-CoV-2 is essential to eliminate environmental sources of the virus and reduce transmission in the community to help keep the pandemic under control.
Currently, mitigation strategies focus on control measures such as social distancing and maintaining good hygiene standards in the home and in public places.
Patterson and team say using Virusend TX-10 could reduce dependence on hygiene products currently used within private residences and common public areas such as offices and hospitals.
“The development of disinfectants such as Virusend TX-10 and others is important as we continue efforts to reduce the transmission of SARS-CoV-2,” the team writes.
A pre-printed version of the document is available on bioRxiv * server, while the article is peer reviewed.
Virusend TX-10 reduces viral titer on hard surfaces by at least 4.0 log10 PFU / mL with high titer viral (HT) inoculum after contact times of 1 minute and 10 minutes. When low titer (LT) inoculum was used, TX-10 reduces the virus titer by at least 2.31 log10 PFU / mL at both 1 minute and 10 minute contact time. The diagonal pattern represents the cytopathic effect caused by TX-10 and the solid black represents the infectious virus titer after each treatment. The Limit of Detection (LOD) (3.0log10 PFU / mL) is shown in the graph with a dashed red line.
Potential transmission tanks for indirect contact
In the absence of an effective vaccine to protect against SARS-CoV-2, efforts to control transmission are limited to measures such as social distancing, restricted travel, hand hygiene, and infection control in public places and families.
Studies have shown that SARS-CoV-2 can remain viable on surfaces such as stainless steel and plastics for up to 72 hours. In solutions such as respiratory droplets, the virus can remain infectious for up to 14 days at a temperature of 4 ° C, seven days at room temperature, and one or two days at 37 ° C.
Contaminated surfaces and solutions are, therefore, potential transmission tanks by indirect contact, the risk of which could be reduced through effective decontamination in common and public places.
Disinfectants containing 75% ethanol and 10% sodium hypochlorite have been shown to reduce SARS-CoV-2 titers by at least 2.0 log10 PFU (plaque forming units) per mL and 3.25 log10 PFU / mL, respectively, within 5 minutes.
The World Health Organization (WHO) recommends diluting household bleach in a ratio of 1: 100 to reduce irritation and ensure contact times of 10 to 60 minutes when decontaminating surfaces and cleaning objects.
What did the stallion involve?
Patterson and the team used surface inactivation and cytotoxicity assays and solutions to test the effectiveness of Virusend TX-10 in inactivating SARS-CoV-2.
On surfaces, Virusend TX-10 reduced the high and low titers of infectious SARS-CoV-2 below the limit of detection within 1 minute.
The disinfectant reduced the high titer inoculum by at least 4.0 log10 PFU / mL and low titer of at least 2.3 log10 PFU / mL.
Incubating a solution with Virusend TX-10 for one minute also reduced the high and low titer inoculum below the limit of detection within one minute.
“Here we present evidence that Virusend TX-10 can reduce the SAR-CoV-2 virus within one minute both in solution and on the surface,” the team writes.
An important step towards pandemic control
The researchers say ensuring that disinfectants are highly effective against SARS-CoV-2 is an important step towards eliminating environmental sources of the virus and controlling the COVID-19 pandemic.
“Virusend TX-10 can reduce the demand pressure on existing hygiene product resources,” they write.
The team says this disinfectant is “highly suitable” for rapidly decontaminating private homes and public spaces such as hospitals and offices.
“The development of disinfectants such as Virusend TX-10 and others is important as we continue efforts to reduce the transmission of SARS-CoV-2,” the team concludes.
*Important Notice
bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be considered conclusive, guide health-related clinical practice / behavior, or treated as consolidated information.
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