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Scientists from Geneva and Italy have just confirmed, in recent research, a link between the gut microbiota and brain diseases, including Alzheimer’s.
The human gut microbiota, formerly called human gut flora, is defined as the collection of microorganisms (archaea, bacteria, fungi, and viruses) of the human digestive tract, i.e. the gut microbiome and the entire system. gastrointestinal.
It constitutes a reservoir of enzymatic activities essential for digestion and human physiology and therefore influences health.
The team from the University of Geneva (UNIGE) and the University Hospitals of Geneva (HUG), with their Italian colleagues, have shown, according to the University of Geneva, a clear correlation between the gut microbiota and the appearance of plaques. amyloid in the brain, which heralds (onset) Alzheimer’s disease.
Some gut bacteria release lipopolysaccharides and short-chain fatty acids that can reach the brain via the blood and cause amyloid disease and neurodegeneration.
Alzheimer’s disease is the most common cause of dementia. Incurable, it directly affects nearly a million people in Europe, not to mention the sick and society as a whole.
In recent years, the scientific community has suspected that the gut microbiota plays a role in the development of the disease.
Scientists then continued research to confirm that there is a correlation between an imbalance in the gut microbiota and the development of amyloid plaques in the human brain.
They are at the origin of the neurodegenerative disorders characteristic of Alzheimer’s disease. The proteins produced by some intestinal bacteria, identified in the blood of patients, could in fact modify the interaction between the immune system and the nervous system and trigger the disease.
The team’s research results, made public in the Journal of Alzheimer’s Disease, allow us to consider new preventive strategies based on modulating the microbiota of people at risk, according to the Technosciences.net website.
“We also found an association between an inflammatory phenomenon found in the blood, some gut bacteria and Alzheimer’s disease,” he continues.
“Hence the hypothesis that we wanted to test here: could inflammation of the blood be a mediator between the microbiota and the brain?”, Indicated the neurologist Giovanni Frisoni, director of the HUG memory center and professor at the Department of Rehabilitation and Geriatrics of the UNIGE Faculty of Medicine.
“We had previously shown that the gut microbiota profile in Alzheimer’s disease patients was altered compared to people without Alzheimer’s disease,” he explains.
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