The Corona vaccine timeline and the separation between the two doses are obstacles for Pfizer and Moderna



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A long time lag and complex transfer procedures are a major obstacle and challenge for Corona vaccine developers in the final race to announce clinical trial results. Experts have announced that Pfizer vaccine, which has been shown to be 90% effective in preventing Corona, is addressing a new problem, namely the issue of vaccine distribution, as the Coronavirus vaccine requires two Pfizer injections within 3 weeks. , which could make the dispensing process more complicated, as it requires Double-dose is double the number of vials, syringes, refrigerators and clinic visits at a time when these resources are already limited.

According to the “Insider” website, the Pfizer vaccine requires two doses to achieve this high efficacy, as the vaccine is administered with a three-week interval last July. Pfizer said the researchers observed the highest level of virus-equivalent antibodies one week after the second dose for the participants.

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Many other vaccines also require subsequent doses to be more effective, including one that protects against measles, mumps, and rubella.

Other candidate trials for the coronavirus vaccine also include a double dose: participants in the Moderna clinical trial receive two doses four weeks apart and try one AstraZeneca Continuous results of each vaccine dose and two doses per month apart.

But the two-dose vaccine presents supply chain challenges and the possibility that not everyone will return to the doctor’s office for the second dose.

The double-dose vaccine requires twice as much ampoules, syringes, refrigerators and clinic visits at a time when these resources are already limited.

And he needs a vaccine Pfizer Additionally, shipping and storage are minus 94 degrees Fahrenheit (minus 70 degrees Celsius) and this poses a formidable challenge for distribution in developing countries, especially in locations with no widespread electricity or health facilities.

Additionally, it can be difficult to get 100% of vaccine recipients to return for a follow-up dose.

“The more complex the program, the harder it is to get people to participate,” said Walt Orenstein, vaccination specialist and former director of the US National Immunization Program.

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For example, research shows that less than a third of young women who receive the first vaccine from the HPV vaccine (HPV) – which targets viruses more primarily than causing cervical cancer – return the two remaining doses to complete the series.

Scientists haven’t been able to study the new Corona virus long enough to determine how long immunity will last, but some evidence indicates that people may be reinfected. Research has found that coronavirus antibodies dissipate after weeks or months, which could mean that our immunity, whether it was produced in response to an infection or a vaccine, can be just as transient. Our immune system has more than just a line of defense, however, there are still many questions about immunity to the virus.

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