The basic concepts lay the foundation for personalized immunotherapy

Reviewed by Emily Henderson, B.Sc.November 23, 2020

Personalized immunotherapy for cancer and more introduces personalized immunotherapy with multidimensional analysis models to determine the best immunotherapy plan for patients.

The book introduces readers to some basic concepts that lay the foundation for personalized immunotherapy: the development of an important histocompatibility complex (MHC), the genome profiling of T lymphocytes and cancer cells, and genome-wide association studies. . The chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared to familiarize readers with current research practices.

Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information on T cell screening, tumor neoantigen cloning, primary tumor cell culture for T cell cloning, bioinformatics strategies for understanding the biology and T cell and primary tumor cell function and new developments in T-cell adoptive immunotherapy research.

These developments include T cell gene therapy and T cell gene editing, transgenic T cells to increase affinity with cancer cells such as CAR T cells and TCR T cells, and systematic modeling of specific polyclonal T cells. and biobank technology.

Main features:

• Introduces readers to the basic concepts of personalized medicine and immunotherapy
• It features up-to-date information on immunological tests used in research
• It presents an overview of T-cell immunotherapy and cloning techniques
• It presents an overview of cancer cell bioinformatics and its role in immunotherapy
• Includes new developments and references for personalized immunotherapy techniques (T cell gene therapy and T cell gene editing, transgenic T cells targeting CAR T cells and TCR T cells, and polyclonal T cell modeling)
• Includes a section on biobanks
• It presents information in an easy-to-read format for a wide range of readers
• Bring input from experts with over 30 years of experience in personalized immunotherapy

Personalized immunotherapy for cancer and more is an ideal manual for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in new developments in these fields will also benefit from the information provided.