[ad_1] Gene modification nucleases such as CRISPR / Cas9 can efficiently create double-stranded breaks at a target locus in the genome. Often, double-stranded breaks are subsequently repaired by non-homologous end-junction mechanisms, leading to insertions and deletions (indel). One strategy, called homology-directed repair (HDR), is used to obtain gene knock-in patterns …
Read More »Modifying Cas9 can improve the efficiency of gene editing
