new treatment perspectives linked to the microbiota

From an animal experiment, INRAE ​​researchers have for the first time provided evidence that intestinal inflammation and the alteration of the accompanying microbiota can support each other and generate chronic disease. “Thus, they show that the simple generalization of inflammation can permanently alter the symbiosis between humans and their microbiota, preventing a return to normal, even 40 days after stopping the induction.” specify the research institute. These results were published November 6 in the journal Microbiome.

A balanced dialogue between humans and their gut microbiota is essential

Crohn’s disease, ulcerative colitis, obesity, diabetes, liver disease, Parkinson’s, Alzheimer’s, autism, cardiovascular disease … Chronic diseases have been on the rise for over 60 years all over the world. INRAE’s work opens up new avenues for patients in terms of diagnosis, preventive nutrition and therapy.

A balanced dialogue between humans and their gut microbiota is essential for maintaining health. From birth, the body provides “the accommodation and the table” the microbiota, which in turn confers on it protective functions, keeping its natural defenses alert and preventing the proliferation of bacteria from the environment within the organism.

Complex interactions

Nothing happens in the intestinal microbiota that does not affect the intestinal wall, immunity and vice versa. These complex interactions ensure the functional robustness of the intestinal ecosystem, which interacts with all organs.

Under normal conditions, even after a serious ailment, for example after taking antibiotics, our microbiota returns to its initial state. In the field of chronic diseases, the INRAE ​​research team put forward the hypothesis – validated since then – that the alteration of the microbiota and the inflammation that accompanies it prevents a return to equilibrium.