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Researchers at Tel Aviv University in Israel have developed a genetic system that, according to them, has shown a great ability to eliminate cancer cells within living bodies, paving the way for effective treatment for this deadly disease. .
The new system is called CRISPR-LNPs, genetically coded lipid nanoparticles that create an enzyme that acts as a scissor that cuts through the DNA of cancer cells.
To prove the new system’s effectiveness, the researchers chose two of the deadliest types of cancer in humans, the first being brain cancer and ovarian cancer.
For example, the average life expectancy of a brain cancer patient after diagnosis is 15 months, while the five-year survival rate does not exceed 3%.
According to the study, using the new treatment in one session in infected mice doubled their lifespan and also increased survival rates from about 3% to about 30%.
“This is the first study in the world that demonstrates that the CRISPR genomic system can be used to effectively treat cancer in a live animal,” said Professor Dan Beer, who led the study in his laboratory at the University of Tel. Aviv.
“It must be emphasized that this is not a chemotherapy treatment. There are no side effects, and a cancer cell treated in this way will not become active again. The Cas9 molecular scissors cut the cancer cell’s DNA,” added Bear. It neutralizes them and permanently prevents reproduction “.
The study, published in the journal Science Advances, opens the door to treating other genetic and chronic diseases such as AIDS, according to the researchers.
Despite the revolution brought about by the “CRISPR” system, according to Behr, therapeutic application in humans still requires an effective and safe delivery system to targeted cancer cells.
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