New compounds identified to “potentially” treat the novel coronavirus

Researchers have discovered novel drug compounds that target a protein that allows the novel coronavirus and other viruses with pandemic potential to replicate in human cells, a breakthrough that could lead to new therapies for COVID-19. Also Read – Covid-19 virus found on imported frozen beef samples

According to researchers, including those from the University of Maryland in the United States, these compounds disrupt the functioning of a protein complex within human cells that are critical for the replication and survival of coronaviruses, including the one that causes COVID-19. Also Read – COVID-19 Live Updates: India Cases Increase to 87,73,479 While Death Toll Reaches 1,29,188

Scientists believe the findings, published in the journal PNAS, could lead to the development of new broad-spectrum antiviral drugs that target viruses such as influenza, Ebola and coronaviruses such as SARS-CoV-2. Also read – COVID-19 treatment: fluvoxamine antidepressant drug can prevent hospitalization

They said the compounds can disrupt the SKI protein complex in the human body that regulates various aspects of a cell’s functioning.

In the current study, the researchers found that this complex also plays a crucial role in helping a virus replicate its genetic material, RNA, within the cells it infects.

“We have determined that disrupting the SKI complex prevents the virus from copying itself, which essentially destroys it,” said study co-author Matthew Frieman of the University of Maryland.

“We also identified compounds that targeted the SKI complex, not only inhibiting coronaviruses, but also flu viruses and filoviruses, such as the one that causes Ebola,” Frieman said.

Using computer modeling, the researchers identified a binding site on the SKI complex and identified chemical compounds that could attach to this site.

From further experimental analyzes, they demonstrated that these compounds have antiviral activity against coronaviruses, influenza viruses and filoviruses such as Ebola.

“These findings represent an important first step in identifying novel antiviral potentials that could be used to treat a large number of deadly infectious diseases,” said study lead author Stuart Weston, also of the University of Maryland.

Such drugs have the potential to treat infectious diseases associated with future pandemics, the scientists added.

(With input from agencies)

Published: November 15, 2020 15:44 | Updated: November 15, 2020 3:45 pm