Neither vitamin D nor sunshine. Calcifediol is effective against coronavirus


Neither vitamin D intake nor sun exposure, which is essential for forming this compound, is useful for strengthening the immune system against covid-19, concluded a clinical trial by the Maimónides Institute for Biomedical Research in Córdoba. (IMIBIC) and Rainha Sofia hospital from the same Spanish city.

however, the country, the researchers found an element in the generation of vitamin D that has been shown to be effective: calcifediol, a compound that acts as a precursor for the generation of vitamin D at levels that neither food nor the sun can reach.

Calcifediol, also known as calcidiol or 25-hydroxyvitamin D (25-OH-D), is a compound that is produced in the liver by a chemical reaction (hydroxylation of vitamin D3) thanks to an enzyme, an organic molecule that acts as a catalyst . That is, the generation of vitamin D requires a previous biotransformation.

The compound analyzed by the institute and the hospital of Córdoba is almost completely absorbed and rapidly increases the concentrations of vitamin D in the blood, eliminating the hepatic metabolism. It is at that time that the compound has sufficient concentrations (40-60 ng / mL) to combat the hyperinflammation produced by the cytokine storm that causes coronary artery virus associated acute respiratory disorder (ARDS) syndrome.

After a pilot study, randomized and open to 76 patients, the follow-up of another 300 cases from 15 hospitals was added. According to the pulmonologist Luis Manuel Entrenas, it has been shown that calcifediol “acts as an immunomodulator”, that is, a stimulator of the body’s immune system to defend itself against the virus, reducing “blood clotting” and therefore the risk of thrombosis.

The effects of this compound reduce acute respiratory distress syndrome which occurs with worsening of covid-19 cases. Of the first 76 patients in the study, 50 received calcifediol and only one had to be admitted to an intensive care unit (ICU). Half of the other 26 received a placebo and underwent intensive care. The expansion of the study is already underway and the results are promising, say the researchers.


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