[ad_1]
A COVID-19 vaccine based on bivalent measles could be an effective solution to address two significant threats to public health.
COVID-19 vaccine vials illustration. Image: Igor Golovniov / SOPA Images
Based on measles virus COVID-19
the vaccine would perhaps be able to prevent them COVID-19 and measles, based on a new test. According to the study authors, a measles-based virus COVID-19 the vaccine could be given as part of routine measles immunization programs.
In the study, published in the journal PNAS, the researchers report to COVID-19 vaccine candidate based primarily on a live attenuated measles virus.
SARS-CoV-2, the virus that causes COVID-19 , killed more than 1 million people worldwide, underscoring the urgent need for an effective vaccine.
Michael Muhlebach and colleagues explored the opportunity to use a live attenuated measles virus as a vector for a coronavirus vaccine. The authors inserted the gene for the SARS-CoV-2 spike protein into the pressure genome of the measles virus used in measles vaccines.
Sera from mice or hamsters vaccinated with this recombinant virus contained antibodies capable of successfully neutralizing SARS-CoV-2 and measles virus.
Cytotoxic T cells from vaccinated mice selectively killed cells expressing the SARS-CoV-2 spike protein upon stimulation with the spike protein.
The antibody and cytokine ranges in the vaccinated mice had kept pace with a Th1 polarized immune response, suggesting a low risk of antibody-dependent enhancement-like immunopathologies and enhanced respiratory disease.
In the fashion of hamsters and mice, vaccinated animals showed a decrease in hundreds of viruses and less extreme pathology following a SARS-CoV-2 infection than unvaccinated animals.
Source link
