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A recent study looked at possible links between the severity of the Covid-19 pandemic and the deterioration of our environment caused by chemicals. This new light points to endocrine disruptors, these everyday pollutants that can be involved in severe forms of Covid-19.
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[EN VIDÉO] 22% of the population would be more vulnerable to the complications of covid-19 About 1.7 billion people, or 22% of the world’s population, are believed to have health conditions that can cause complications if infected with the Covid-19 virus. This is the result of a study put online by the CDC based on statements collected during the month of April 2020 in the United States.
Some people infected with SARS-CoV2 have not symptom greater ; others become seriously ill. The scientific literature has shown that age, sex, weight and pre-existing chronic diseases play a role in the substantial variability over the course of COVID-19. Other factors such as environmental pollutants he could also be involved, particularly by promotingobesity and chronic diseases.
Indeed, ” our new study finds exposure to disturbing chemicals endocrine system (the endocrine disruptors or PE) could interfere with various biological signals of the human body, playing an important role in the severity of Covid-19 », Explains Karine Audouze, Professor at the University of Paris, which carried out this study within the T3S * laboratory (University of Paris, Inserm) and which was published on November 19, 2020 in the journal International environment.
A bioinformatics approach to identify the possible role of EP
Exposure to endocrine disruptors has been associated with chronic metabolic diseases such as diabetes, obesity or some heart conditions, all of which can contribute to severity of Covid-19. To better understand the relationships between them substances and the increased risk of Severe Covid-19, the researchers used a bioinformatics approach.
They then identified the biological pathways (e protein key paths) that were associated both with the modes of action of the PEs and, in parallel, a chronic diseases promote the severity of Covid-19. They were then able to identify common pathways, which in this case are involved in the body’s defense against pathogens (the immune response).
The authors suggest that there is a possible relationship between severity of this pandemic and the deterioration of our environment by chemical products. On the one hand, they point out that populations highly exposed to ED deserve the best prevention possible and, on the other hand, that the key proteins of the biological pathways that are both targeted by PE and related to the severity of Covid-19, may represent possible targets for therapies futures.
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