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Researchers have discovered, in a new study, a hormone in the body that may be an ideal treatment for weight loss and weight loss.
The hormone is called “lipocalin-2”, and it has been shown to stop the feeling of hunger in mice, and increase the feeling of satiety in them, according to a new study published yesterday in the medical journal. “E-Life”.
The study’s data indicates that the hormone “lipocalin-2” could be developed into an effective and safe treatment for obesity and that it could be used as a potential treatment for people suffering from obesity, whose natural signals of feeling full. they no longer function normally.
The hormone is mainly produced by bone cells and occurs naturally in mice and humans. Studies in mice have shown that long-term administration of “lipocalin-2” to animals reduces food intake and prevents the increase in weight, without slowing down the metabolism.
“We wanted to know if it was lipocalin,” says lead author of the scientific research, Peerstera Luana Petropolo, who was a researcher at Columbia University at Irving Medical Center in New York City at the time of the study and now works at the study. ‘Helmholtz Diabetes Center. -2 “It has similar effects on humans and if a dose of it will be able to cross the blood-brain barrier.”
The study team first analyzed data from 4 different studies of people in the United States and Europe who were of normal weight, overweight or obese. In each study, subjects were given a meal after an overnight fast and the amount of the hormone “lipocalin” was studied. 2 “in the blood before and after a meal.
The researchers found that in the normal weight subjects, there was an increase in “lipocalin-2” levels after eating a meal, which coincided with their satisfaction level after eating, and conversely, they found that the people who were overweight or obese decreased “lipocalin-2” levels. “They eat it after a meal.
Based on the post-meal response factor, the researchers classified the subjects as non-responders or responders and indicated that non-responders who did not show an increase in lipocalin-2 after a meal had greater waist circumference and more signs. of metabolic disease, including an index. Body mass, body fat, increased blood pressure and increased blood sugar.
After the researchers verified that the hormone ‘lipocalin-2’ could be transmitted to the brain, the team investigated whether treatment with it could reduce food intake and prevent weight gain. To be sure of this, they tested the hormone on monkeys for a week and the result was a percentage decrease. 28% of their food intake compared to before they underwent hormone therapy, and their food intake was 21% less than other monkeys treated with saline only.
Furthermore, after only one week of treatment, measurements of body weight, body fat, and blood lipid levels showed a downward trend in treated animals.
Lead author of the study, Stavroulla Costini, professor of cellular physiology and biophysics at Columbia University’s Irving Medical Center, concludes: “We have shown that lipocalin-2 passes into the brain, makes its way into the hypothalamus, and stops taking of food in non-primates. Humanity “.
“Our results show that the hormone can suppress appetite with negligible toxicity and set the stage for the next level of ‘lipocalin-2’ test for clinical use in humans.”
© Sputnik
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