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FRIDAY, December 4, 2020 (HealthDay News) – According to a study published online December 2 in The BMJ.
Dagrun Slettebø Daltveit, of the University of Bergen in Norway, and colleagues examined the correlations between birth defects and cancer from birth to adulthood in a nested population-based case-control study with 62,295 cancer cases and 724,542 controls born between 1967 and 2014.
The researchers found that for people with severe birth defects compared to those without, the cancer odds ratio was 1.74. The odds ratios for cancer were 1.54 and 5.53 for individuals with non-chromosomal birth defects and for those with chromosomal abnormalities, respectively. Many structural birth defects were related to later cancer in the same organ system or anatomical location. For both non-chromosomal and chromosomal abnormalities, the odds ratio of cancer increased with the number of defects and decreased with age. For individuals with any non-chromosomal birth defect, the odds ratio of cancer was lower in adults than in adolescents and children (odds ratios, 1.21, 1.58, and 2.03 for those age 20 years, 15 to 19 years and 0 to 14 years, respectively). Among those with chromosomal abnormalities, the overall relative risk of cancer was reduced from 11.3 in children to 1.50 in adults.
“The most important implication of our findings is to provide additional rationale for further studies on the molecular mechanisms involved in developmental disruptions underlying birth defects and cancer,” the authors write.
Abstract / full text
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