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Pfizer and its German partner BioNTech decided to take this action just days after announcing their vaccine had a 95% success rate. The Modern Society vaccine showed nearly 95% efficiency, that company announced, referring to early research results.
Luca Hutchison, a computer biologist, has volunteered to test Modern’s covida-19 vaccine. After receiving the second dose, her arm swelled to the size of a ‘goose egg’.
He can’t be sure if he received a placebo or a vaccine, but within hours the healthy 43-year-old experienced pain in his muscles and bones and his temperature was 38.9 ° C.
“I started shaking. There was an alternating feeling of cold and hot,” said Hutchison.
He says the public should be better prepared than he is, as people can face intense, albeit temporary, side effects. Some experts agree.
“What about the reactogenicity of the vaccine? Although it is safe and will not cause long-term problems, as the public will see when they start getting vaccinated,” he asks. Deborah Fuller, a vaccinologist at the University of Washington in Seattle.
Florian Krammer, a vaccinologist at the Icahn School of Medicine, says these temporary reactions shouldn’t deter people from getting vaccinated.
“Hand pain, fever and fatigue are annoying, but they’re not dangerous. I’m not worried,” he said.
Most people will not have defined serious side effects such as those that interfere with daily activities. Less than 2% of respondents who received a vaccine developed by Pfizer and Moderna had a high fever between 39 ° C and 40 ° C.
As for other side effects, fatigue was felt by 9.7% of the participants, muscle pain in 8.9%, joint pain in 5.2% and headache in 4.5% of the participants. who received the vaccine produced by Moderna. For the Pfizer / BioNTech vaccine, the numbers were lower: serious side effects included fatigue (3.8%) and headache (2%).
“Side effects mean the vaccine works well”
“This is more reactogenic than is usually seen with most flu vaccines, even at high doses,” he says. ArnoldQuantity, an epidemiologist at the University of Michigan.
Furthermore, each individual who is vaccinated should receive two doses, and reactogenicity is generally higher after the second dose.
“The side effects mean the vaccine works well. That means you had such a good immune response on the first dose and now you see the effects,” he said. Drew Weissman, a University of Pennsylvania immunologist, added that companies should warn people about the side effects they can expect.
Ian Haydon received the highest dose of Moderna vaccine in the first study, around 250 micrograms, after which the company decided to reduce the dose to 100 micrograms, writes Science.
Twelve hours after receiving her second injection in May, Haydon experienced a chill such as headache, body aches, fatigue, nausea, and a temperature of 39.6 ° C. She later threw up and passed out before symptoms subsided. , Haydon explained.
But Haydon says his experience was a “small price to pay” in order to return to a normal life.
The long-term side effects of the mRNA vaccine remain theoretical. They include the possibility that people with lupus, whose disease is triggered by antibodies against their own genetic code, could experience worsening due to a vaccine-stimulated immune response, he says. SarfarazHasni, Director of Clinical Lupus Research at the National Institute of Arthritis and Musculoskeletal and Skin Diseases.
But there is currently no evidence that mRNA vaccines cause or worsen autoimmune diseases, he says BettyDiamond, an immunologist and rheumatologist at Northwell Health’s Feinstein Institute for Medical Research.
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