Guillermo Ruíz Esparza, leader of the research group on the development of molecular nanosystems in the health sciences division of Harvard-MIT, assures that medicine is now more than just taking a pill to improve ourselves.
“Today there are exponential technologies such as digital medicine, robotics, nanotechnology, tissue engineering, molecular drugs, telemedicine, genomics,” he says.
Ruíz Esparza’s group works at the intersection of medicine, engineering and biology to create innovation. His work is inspired by figures such as Leonardo Da Vinci who was an engineer, anatomist, physiologist and created the Mona Lisa, the most perfect work from different perspectives.
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“Nanotechnology is smaller than even a virus. Size is very important because physical laws change according to properties. We take advantage of these properties and apply them to solve medical problems,” Ruíz Esparza explains during the entrepreneurship forum. INCmty.
The research group for the development of molecular nanosystems of the division of health sciences at Harvard-MIT, led by Guillermo, uses nanotechnology in tissue engineering, imaging agents, drug delivery to specific tissues.
They combine engineering, medicine, nanotechnology and other sciences in nanomedicine.
One of the most recurring problems with medications is that they are not effective in delivery i.e. you take something and something else hurts you.
According to the figures “of every 10,000 drug molecules we take, only one reaches the required place and the others are metabolized or go to other tissues, generating negative effects,” explains Ruíz.
The MIT team managed to create nanovectors, for example, by encapsulating drugs in nanoparticles (they are encapsulated in biodegradable materials).
Nanovectors have several layers that help us in a fast or slow release of the compound: protective or mimetic layer, proteins that work like GPS to help you recognize precise cells.
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Therapies of the future
“This innovation can be used not only in nanoparticles, but also with modified genes. They can travel through the bloodstream to treat heart problems. For example, it has been used for heart failure, bone cancer, ovaries. They can reach the cell nucleus, which opens up opportunities for new therapies, ”adds the expert.
These innovations mark new frontiers for medicine. Guillermo Ruíz Esparza explained that: “We have progressed a lot in 3D printing of biological forms, with different materials to create each component of muscles, bones, tendons. Chips were also generated to produce specific tissues in regenerative therapies. In hydrogels for synthetic leathers or organ coatings and thus avoids the effectiveness of 25% of existing ones “.